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45% (75/143), 47.55% (68/143), 19.71% (67/34, 80.29% (273/34, respectively. Our results demonstrated that the risk of persistent infection (aRR=2.50, 95%CI 1.55-4.02) and from negative to positive (aRR=4.55, 95%CI 2.52-8.23) in the low level of folate were significantly higher than that in the high level of folate, especially the risk of homotype persistent infection (aRR=2.72, 95%CI 1.51-4.9. The risk of persistent infection (trend χ2=20.62, P less then 0.001), from negative to positive (trend χ2=31.76, P less then 0.001), pers