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Although suprisingly low high quality of evidence supported the survival advantage of CIV compared with IIV, huge RCTs with lasting follow-up are essential to demonstrate success advantages. Care should be provided for off-label use of CIV of Endostar. This situation report describes the clinical signs and symptoms of a calf with focal diplomyelia during the degree of the fourth lumbar vertebra. Magnetic resonance imaging (MRI) images and histological conclusions regarding the affected spinal