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Particularly, therapy with TAK242, an inhibitor of TLR4-NF-kB signaling pathway, ameliorated the macrophage activation which usually would exacerbate the inflammation. Therefore, the present study unveiled for the first time at molecular degree that the scarcity of germ cell differentiation therefore the enormous immune effect tend to be significant abnormalities in the cultured testis tissues.Insulin-like growth aspect binding protein 3 (IGFBP3) is a multifu