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Radical cystectomy (RC) has the potential for profound changes to health-related quality of life (HRQOL). To evaluate a broad range of HRQOL outcomes in a large RC cohort. A single-center prospective study enrolled RC patients from 2008 to 2014. We collected 14 separate patient-reported outcome measures at the presurgical visit and at 3, 6, 12, 18, and 24 mo after RC. To visualize the patterns of recovery over time across domains, we used generalized estimating equations (GEEs) with nonlinear terms. Given substantial differences in pati