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6%] vs. 8/19 [42.1%], P = 0.04). Among the patients with stage 3-5 CKD, LDA therapy during pregnancy was associated with a lower risk of severe preeclampsia (odds ratio = 0.22, 95% confidence interval 0.074-0.993; P = 0.049). LDA therapy during pregnancy can reduce the risk of severe preeclampsia in patients with stage 3-5 CKD. Prospective studies are needed to further explore the preventive effects of aspirin on preeclampsia in patients with stage 1-2 CKD. LDA therapy during pregnancy can reduce the risk of severe preeclampsia in patie