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According to WHO, the death rate of COVID-19 exceeded that of SARS and MERS in view of which COVID-19 was stated as community health crisis of international concern. Coronaviruses are positive-sense RNA viruses with single stranded RNA and non-segmented envelopes. Recently, genome sequencing verified that COVID-19 is comparable to SARS-CoV and bat coronavirus, however the significant supply of this pandemic outbreak, its transmission, and mechanisms regarding its pathogenicity