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How Does Medication For ADHD Work? The most commonly prescribed medications doctors prescribe to manage ADHD work by increasing levels of chemicals in the brain that are known as dopamine and norepinephrine. They come in both short-acting versions and extended-release. Medicines affect everyone differently, so it may take some time to determine the right dosage and medication for you or your child. Lifestyle changes can ease symptoms in addition to medication. Methylphenidate Methylphenidate is a c