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Our current analysis suggested VEGF gene polymorphisms may be associated with PCOS risk, which is possible to be expected to become biomarkers of early detection for women. Copyright 2020 The Author(s).OBJECTIVES Little is known about the length of working life, even though it is a key indicator for policy-makers. In this paper, we study how the length of working life at age 50 has developed in the U.S. from a cohort perspective. METHODS We use a large longitudinal sample of U.S. Social Security register data that covers close to 1.7 million individ