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ate the optimal dose of taurine supplementation and long term potential effects on the offspring. The CCT complex is an important mediator of microtubule assembly and intracellular protein folding. Owing to its high expression in spermatids, CCT knockdown can disrupt spermatogenesis. In the present report, we therefore evaluated the in vivo functionality of the testis-specific CCT complex component CCT6B using a murine knockout model system. A CRISPR/Cas9 approach was used to generate mice, after which candidate gene expression in these
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