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How Does Medication For ADHD Work? The stimulants are the most common ADHD drugs prescribed. They increase the levels of brain chemicals called dopamine and norepinephrine. They include amphetamines, methylphenidate and dextroamphetamines (Adderall), and lisdexafetamine (Vyvanse). Doctors typically prescribe these in long-release versions that last between six and eight hours or more. This minimizes ups and downs when the medication is absorbed. Most people will see a reduction in symptoms. Stimulants Medicati