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ADHD Medication - Finding the Right One Finding the best ADHD medicine requires a lot of trial and error. Many factors influence effectiveness, including the individual's metabolism, the effects of the drug and how a medication interacts with other medications and supplements. The stimulants may take some time to work, but they help improve attention, focus and impulsivity. They also boost brain chemicals such as dopamine and adrenaline. Stimulants The stimulants, also referred to as uppers, boost the b