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How Does ADHD Medication Work? Many people discover that ADHD medications can help them focus, concentrate and manage their impulsive behavior. It may take some time to find the most effective drug and dosage for each person. Certain medications can affect children's sleep patterns. If they're sleeping better than they did before it's likely an indication that the drugs are working. 1. Stimulants Stimulants are among the most commonly prescribed prescription drugs that doctors use to t