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ADHD Medications For Adults and Teenagers When ADHD medication starts to work properly, they should notice that they are able to concentrate for longer durations. They may also be more prone to falling asleep. Adults are most commonly prescribed stimulants for ADHD. They can be either immediate-release or long-acting. Long-acting formulations prevent "crash" effects that occur when stimulant medications wear off. Methylphenidate Methylphenidate is a central nervous system st