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The utilized information in this analysis is based on various databases (PubMed, Science Direct, Wiley on the web library, Wanfang Data, Web of Science) through a search using the keyword "Gentiana" within the period of 1981-2019. Besides, other ethnopharmacological information was acquired from Chinese herbal classic books and Chinese pharmacopoeia 2015 version. The plants from Gentiana genus have a lengthy tradition of varied , pharmacology, toxicology and molecular pr