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Combined CO and exercise led to body mass reduction and a metabolic state similar to control OR rats and prevented the exercise-induced increase in bone fragility. CONCLUSIONS CO and aerobic exercise training prevent obesity and metabolic sequelae of nutrient excess while stabilizing bone physiology. © 2020 The Obesity Society.Atherosclerosis with associated cardiovascular diseases remains one of the main causes of disability and death worldwide, requiring development of new solutions for prevention and treatment. Macrophages are the key