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How to Choose the Best ADHD Medication for Adults The stimulant drugs like methylphenidate and amphetamine work by boosting and balancing brain chemicals. Doctors often prescribe them as pills, liquid or patches. Healthcare professionals also utilize drugs known as norepinephrine-reuptake inhibitors and alpha-2 agonists for treating ADHD. These medications are usually used "off-label", since they are FDA-approved for different ailments. Stimulants The stimulants are among the most frequently ADHD medication prescribed. They increase levels of the br