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Methods Ten C57BL/6 expecting mice were randomly divided into control group (physiological saline subcutaneous injection) and prenatal smoking visibility (PNE) team (smoking subcutaneous injection ) by using a random number table. Postnatal day 0 (P, postnatal day 14 (P14) and postnatal time 25 (P25) offspring mice were gathered for subsequent experiments. The offspring mice were divided into offspring control group and offspring PNE group according to the maternal gro