http://pd169316inhibitor.com/a....n-fnirs-study-the-re
An association between RAD54L germline mutation and POLE exonuclease domain hypermutated cancer is not reported before. We present an unusual instance of a 41-year-old Chinese female with a right-sided colon adenocarcinoma which harboured a (p.P286R) POLE somatic mutation. Genomic analysis had been performed using the Illumina HiSeq Sequencing platform, which, identified MSS tumour with a (c.1093_1169 + 15dup) germline mutation in RAD54L gene and tumour mutation burden of 377.0 Muts/Mb. Predicated on our report a un
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