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ADHD Medication - Ritalin Ritalin, a chemical called methylphenidate, is effective in managing ADHD symptoms in adults. It can make you feel "up," awake, alert, and full of clarity. ADHD medications work by affecting dopamine and norepinephrine which are two brain chemicals. The majority of ADHD medications, such as Ritalin and Concerta, are stimulants. There are also nonstimulant medications. is a c