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There is evidence suggesting that tryptophan (TRP)-kynurenine (KYN) pathway dysregulation is involved in the pathophysiology of schizophrenia and is regulated by inflammatory cytokines. The study investigate for the first time whether this dysregulation occurs in advanced stages of the disease as a byproduct or emerges as one of the early and inherited manifestations of schizophrenia. Sera of 148 patients with schizophrenia spectrum disorders (SCZ), 139 unaffected siblings (SI and 210 controls were investigated. Serum interleukin (IL)-1