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How Does Medication For ADHD Work? Stimulants are the most commonly prescribed ADHD medications. They increase the levels of brain chemicals called dopamine and norepinephrine. These include methylphenidate, amphetamines and dextroamphetamines (Adderall), and lisdexafetamine (Vyvanse). Doctors often prescribe these in long-release forms that last for six to eight hours or more. reduces the fluctuations when th