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How Does Medication For ADHD Work? The most common medications that doctors prescribe to treat ADHD are effective by increasing levels of chemicals called dopamine and norepinephrine inside the brain. They come in both short-acting and extended-release forms. Medicines affect everyone differently and it can take some time to locate the right medicine and dose for your child or yourself. Lifestyle changes can ease symptoms, in addition to medications. Methylphenidate Methylphenidate, a central nervou