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The liver and kidneys are crucial body organs for the cleansing, metabolic rate, and excretion of HML. However, data regarding the effect of HML on nontarget organisms are scarce. The present research aimed to determine the mechanism of dose-dependent hepatorenal toxicity of HML in rats. Twenty-one rats had been split into three equal groups that obtained listed here remedies via oral intake daily for 14 days group 1, typical saline; group 2, reduced dosage of HML (1/80 LD50 ); tea