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The Biochemical Nuances of SARMs: Mechanisms of Action and Tissue Specificity
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At the molecular level, SARMs exhibit high specificity for androgen receptor (AR) coactivator recruitment, which allows them to distinguish between anabolic and androgenic tissues. Unlike traditional androgens, SARMs do not undergo enzymatic conversion to dihydrotestosterone (DHT) or estradiol, minimizing off-target effects such as gynecomastia or acne.