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88, -2.51]). At 24 months, there were statistically significant mean improvements in QoL (ΔPDQ-39=-7.74 [-12.40, -3.07], ΔEQ-5D =11.18 [6.90, 15.45]) and ADL (ΔUPDRS II =-3.88 [-5.34, -2.42]), and Off time (-4.21 [-5.16, -3.26] hours/day). Impact of CLES on significantly reducing Off time/day was observed to be rapid and durable (i.e., remained consistent across 24 months). Most QoL and ADL measures showed a consistent pattern of improvement with initiation of treatment and remained significantly improved from baseline at 24 months. Imp