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We perform phantom and in vivo mice imaging experiments to verify the proposed method, and the results show significant image quality and resolution improvement.We focus on a fundamental task of detecting meaningful line structures, a.k.a., semantic line, in natural scenes. Many previous methods regard this problem as a special case of object detection and adjust existing object detectors for semantic line detection. However, these methods neglect the inherent characteristics of lines, leading to sub-optimal performance. Lines enjoy muc