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In addition, HER2 expression ended up being increased in persister cancer tumors cells in 11-18 cell line harboring EGFR L858R or HCC827 cellular line harboring EGFR exon 19 deletion after the visibility to erlotinib in vitro and in vivo. The mixture of erlotinib and T-DM1 revealed an excellent inhibitory impact on cell expansion compared with those of this erlotinib or T-DM1 alone in either 11-18 or HCC827 cells in vitro. The combination therapy also induced a significantly higher inhibitory i