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How Does ADHD Medication Work? The drugs help reduce ADHD symptoms by increasing the levels of Dopamine and Noradrenaline. These are chemicals that transmit messages between brain cells. The most commonly prescribed stimulants include methylphenidate and Atomoxetine. Finding the right dose and dosage can require a lot trial and trial and. Open, honest communication with your doctor is crucial. Stimulants The stimulant drugs prescribed for ADHD