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The shift in Th17/Treg balance, in favor of increased Treg frequencies, adds to gut mucosal permeability, resistant disorder, and microbial translocation, subsequently leading to chronic immune activation/inflammation and illness development. Of particular interest, Th17 cells and Tregs share developmental roads, with changes in the Th17 versus Treg fate decision influencing the pro-inflammatory versus anti-inflammatory reactions. The differentiation and function of Th17 cells and Tregs