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Mycoplasma pneumonia of swine (MPS) is caused by Mycoplasma hyopneumoniae (M.hp) and it is a standard chronic respiratory disease of pigs. Recently, a genetically selected variation regarding the Landrace pig (Miyagino L2) features a reduced incidence of pulmonary MPS lesions. We investigated the pathological and immunological faculties of MPS opposition during these pigs (n = 24) by researching with the regular landrace pig (control n = 24). The pathological MPS lung lesion rating