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Most Effective ADHD Medication For Adults The majority of adults report that medication can help ease their ADHD symptoms, so that they can focus and feel more relaxed, as well as have better relationships. Other treatment options like psychotherapy can also be assisted with medication. Adults who suffer from ADHD are most likely to benefit from stimulants. These include methylphenidate and amphetamine compounds. Adults may take short-acting medicines often throughout the day or long-acting versions that start working slowly and last 3 to 6 hours. Stimulants Stimulan