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The sensitivity of joint reader evaluation of side-by-side-images reached almost 86% and was not significantly different from TNC images ( = 0.77). All stones larger than 3 mm were correctly detected by side-by-side-evaluation. Dose reduction of 55% could be achieved by omitting TNC scans. Side-by-side-VNC and post-contrast image evaluation enable detection of clinically significant urolithiasis on single-phase split bolus DE-CTU with significant dose reduction. This study shows that single-phase DE-CTU is feasible if VNC imaging is sim