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Objective To summarize the clinical characteristics of high-risk neuroblastoma (HR-N in a single center, analyze the prognostic factors of HR-NB. Methods The clinical data of children with HR-NB who were treated and followed up at the hematology-oncology center of Beijing Children's Hospital from February 1, 2007 to June 30, 2018 were analyzed retrospectively. The clinical features were summarized. Kaplan-Meier method was used for survival analysis and Cox regression was used to analyze the prognostic factors. The last follow-up time