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Objective This study was to explore the role and necessity of muscle mass [fat-free mass index (FFMI) and appendicular skeletal muscle index (ASMI) measured by bioelectrical impedance analysis (BIA)] in nutritional status evaluation of patients with locally advanced (III, IVa) nasopharyngeal carcinoma (NPC). Methods One hundred and thirty locally advanced NPC patients were recruited. Their nutritional status was assessed by albumin (AL, body mass index (BMI), Nutritional Risk Screening 2002 (NRS 2002), Patient generated-Subjective Globa