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CONCLUSION The integrated method coupled 1H-NMR based metabonomics with network pharmacology provided the insights into the mechanisms of TCM in treating CI. Chemoresistance represents one of the main obstacles in treating several types of cancer, including bladder and ovarian cancers, and it is characterized by an increase of cellular antioxidant potential. Nrf2 and YAP proteins play an important role in increasing chemoresistance and in inducing antioxidant enzymes. It has been reported that Ailanthone (Aila), a compound extracted from
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