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We aimed to assess the association between serum potassium and mortality in patients receiving continuous renal replacement therapy (CRRT). We studied 1279 acute kidney injury patients receiving CRRT in a tertiary referral hospital in the United States. We used logistic regression to assess the association of serum potassium before CRRT and mean serum potassium during CRRT with 90-day mortality after CRRT initiation, using serum potassium 4.0-4.4 mmol/L as reference group. Before CRRT, there was a U-shaped association between serum pot