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Thus, extended neoadjuvant chemotherapy with FLOT is safe for customers with locally advanced GC or GEJ tumors.The c-Jun N-terminal kinase 3 (JNK3) signaling cascade is triggered during cerebral ischemia leading to neuronal harm. The current research was performed to determine and evaluate novel JNK3 inhibitors making use of in-silico and in-vitro strategy. A complete of 380 JNK3 inhibitors that belong to different organic groups had been gathered through the formerly reported literary