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A model based on three factors excluding germline BRCA1/2 mutation also yielded high-predictive power in instances from these two cohorts without germline BRCA1/2 mutations AUC had been 0.92 and 0.90, correspondingly. Conclusions The HRD-high phenotype of AYA breast disease customers are deduced from genomic and pathological aspects that are regularly analyzed in the oncology clinic, irrespective of germline BRCA1/2 mutations.Purpose Germline pathogenic variants in BRCA1 (FANCD1) and BRCA2 (FA