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PRODUCTS AND METHODS Hydroalcoholic plant from aerial elements of O. rosea had been obtained and chemically separated so that you can obtain OrEA and separated compounds using line chromatography, HPLC, UPLC and NMR analysis. O. rosea extract and derivatives had been tested from the kaolin/carrageenan (K/C) induced joint disease model on ICR mice. Knee irritation and paw detachment limit were evaluated after intraarticular management of kaolin and carrageenan (4% and 2%, c