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Additional practical exploration employing GTPγ[35S], cAMP-accumulation assay and cAMP reaction factor (CRE)-driven reporter gene assays exhibited slight partial agonist properties of these pyrrolidindiones but acting in addition to the stated focus range. We conclude, that the previously reported actions of such pyrrolidindiones result from an overestimation in line with the way of dimension and so, we cast doubt in the brand-new pharmacophores with H3R agonist task. Patients experiencing d