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We developed a fully automated, two-step deep learning approach for characterizing coronary calcified plaque in intravascular optical coherence tomography (IVOCT) images. First, major calcification lesions were detected from an entire pullback using a 3D convolutional neural network (CNN). Second, a SegNet deep learning model with the Tversky loss function was used to segment calcified plaques in the major calcification lesions. The fully connected conditional random field and the frame interpolation of the missing calcification frames w