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ADHD Stimulant Medication About 70 to 80percent of children and adults with ADHD benefit from stimulants. They ease symptoms by increasing levels of dopamine and norepinephrine. These medicines begin working within 30 to 45 minutes, and last between 3 and 6 hours. They are available as liquid or chewable tablets. Your doctor might prescribe non-stimulant drugs to accompany stimulants. These include the atomoxetine (Strattera) and Guanfacine (Intuniv). Short-acting S