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This proof-of-principle study indicates that targeted NGS analysis of cfDNA with TST170 could be useful for non-invasive detection of gene variants in metastatic CRC patients, providing an assay that could be easily implemented for detecting somatic alterations in the clinic. The primary objectives of this study are to compare the rates of preterm birth; fetal growth restriction and low birth weight between the following groups (1) pregnant women treated for thyrotoxicosis and low-risk pregnancies; (2) between pregnant women with thyrot