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Experimental outcomes from the benchmark datasets reveal that this new deep learning-driven Signal-3L 3.0 yields promising overall performance. The internet server of Signal-3L 3.0 is available at http//www.csbio.sjtu.edu.cn/bioinf/Signal-3L/.Glutamic acid (Glu) is considered the most abundant excitatory neurotransmitter in the nervous system, and a heightened level of Glu may indicate some neuropathological diseases. Herein, three isomorphic microporous lanthanide metal-organic frameworks (MOFs) [(