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ssed in the context of interface stability. Other software is described to determine the druggable proteome by using information related to the chokepoint analysis of the metabolic pathways, gene essentiality, homology to human proteins, functional sites, druggable pockets and fragment hotspot maps.Culture-independent and meta-omics sequencing methods have shed considerable light on the so-called "microbial dark matter" of Earth's environmental microbiome, improving our understanding of phylogeny, the tree of life, and the vast functio