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An association of variants in different genes was found in 21% of cases, including a young woman with severe OP bearing , , and variants. Among genes of uncertain significance analyzed, a potential additional line of evidence has arisen for GWAS candidates and , warranting further studies. While we hope that continuing efforts to identify genetic predisposition to OP will lead to improved and personalized care in the future, the likelihood of identifying actionable pathogenic variants in intriguing cases of idiopathic or familial osteopor