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Most Effective ADHD Medication For Adults The majority of adults report that medication can help ease their ADHD symptoms, allowing them to focus, feel calm and have better relationships. Other treatment strategies like psychotherapy can also be aided by medications. Stimulants are among the most effective medications for treating ADHD in adults. They include methylphenidate compounds as well as amphetamines. Adults can take short-acting medications often throughout the day or long-acting ones that beg