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active in granulocytes. The differences in proteins involved in oxidative response also suggest different redox processes in each cell type. The PRAGUE-17 trial demonstrated that left atrial appendage closure (LAAC) was non-inferior to non-warfarin oral anticoagulants (NOAC) for preventing major neurological, cardiovascular or bleeding events in high-risk patients with atrial fibrillation (AF). To assess the pre-specified long-term (4-year) outcomes in PRAGUE-17. PRAGUE-17 was a randomized non-inferiority trial comparing percutaneous LA