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OBJECTIVE This study aimed to describe the relationship between serum zinc factor and psychological factors on baby blues syndrome in mothers who have a family of smokers. METHODS This research was analytic observational with a cross-sectional design. The research was conducted in Siti Fatimah Hospital Makassar with 70 samples. Smoking and psychosocial aspects were measured using a standard questionnaire. Measurement of serum zinc taken from blood plasma and then examined using the colorimetric method. Postpartum depression was measured us