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The findings tend to be controversial and no research reports have evaluated the consequences of orchiectomy and testosterone replacement on glycerol-induced renal damage. Male Wistar rats were posted to orchiectomy or sham surgery and divided in to four groups SC, sham control rats inserted with NaCl; SG, sham rats inserted with glycerol; OG, orchiectomized rats injected with glycerol; OGT, orchiectomized rats injected with glycerol and testosterone. Testosterone was administered day-to-da